All cancers have mutations, and this is exactly what the immunotherapy is attacking. Ironically, the unique mutations that cause cancer are probably the best targets for treating cancer." ACT therapy used by researchers is different from chimeric antigen receptor T cell (CAR-T) therapy, the most promising immunotherapy for cancer treatment, which has shown remarkable ability to eliminate various kinds of tumors, especially for B cell malignancies, with up to 95% response rates and durable
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complete remission. CAR-T has been approved for use in hematological tumors, but it has not been shown to be effective against solid tumors.
ACT does not involve genetic modification of T cells to target cancer cell antigens, but whether this has an impact on its safety or efficacy remains to be seen. Like CAR-T, ACT technology requires the use of high-dose chemotherapy to destroy existing immune cells, which is itself a dangerous process.
https://www.creative-biolabs.com/car-t/cellrapeutics-chimeric-antigen-receptor-car-technology.htm